People with hard-to-treat schizophrenia have different gut bugs, and medication may be to blame

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People with hard-to-treat, or treatment-resistant, schizophrenia have significantly different gut bugs making up their microbiome compared to people who respond well to treatment and those without the disorder, according to Australian research. The authors say the study suggests that medications may be driving the gut microbiome differences seen in schizophrenia. 

Journal/conference: JAMA Psychiatry

Link to research (DOI): 10.1001/jamapsychiatry.2023.5371

Organisation/s: The University of Queensland

Funder: The study was supported by
Metro South Health Research Support Scheme
grant RSS_2020_071.We also acknowledge funding
from Princess Alexandra Hospital, National Health
and Medical Research Council (investigator grant
2018431 to Dr Gratten and 1194635 to Prof Siskind),
Queensland Centre for Mental Health, University of Queensland (Australian Research Training Program
stipend and tuition fee offset and the Joan
Lawrence Endowment prize for high-achieving
women in neuroscience to Ms Vasileva) and the
Mater Foundation (Drs Gratten and Yang).


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