‘Cancer-cooling’ protein puts bowel cancer on ice

A protein in the immune system can be manipulated to help overcome bowel cancer, according to new research from The Australian National University (ANU).  According to lead author Dr Abhimanu Pandey, from ANU, the protein, known as Ku70, can be activated or “turned on” like a light switch by using a combination of new and existing drugs.

Journal/conference: Science Advances

Link to research (DOI): 10.1126/sciadv.adh3409

Organisation/s: The Australian National University, QIMR Berghofer Medical Research Institute, The University of Queensland, The University of Sydney, The University of New South Wales

Funder: This work was supported by the National Health and Medical Research
Council of Australia under Project and Ideas Grants APP1146864 and APP2002686 (S.M.M.),
CSL Centenary Fellowship (S.M.M.), National Health and Medical Research Council of Australia
under Project Grants APP418100 and APP1059488 (N.T.), Cancer Council ACT Research Grant
(A.M.), John Curtin School of Medical Research PhD Scholarship (A.P.), and Gretel and Gordon
Bootes Medical Research Foundation (A.P.).

Media release

From: The Australian National University

A protein in the immune system can be manipulated to help overcome bowel cancer, according to new research from The Australian National University (ANU).

Bowel cancer claims more than 100 lives in Australia each week, yet around 90 per cent of cases can be successfully treated if detected early.

According to lead author Dr Abhimanu Pandey, from ANU, the protein, known as Ku70, can be activated or “turned on” like a light switch by using a combination of new and existing drugs.

“In its activated state, the protein acts like a surveillance system, detecting signs of damaged DNA in our cells,” Dr Pandey said.

“DNA is the genetic code of life. Damaged DNA is a sign of danger that can turn healthy cells into cancer cells.

“Our research shows that Ku70 can ‘cool off’ cancer cells and mop up damaged DNA. The protein prevents the cancer cells from becoming more aggressive and spreading throughout the body, essentially deactivating them and keeping them in a dormant state.”

Bowel cancer is the fourth most diagnosed cancer in Australia. It’s estimated one in 20 people will be diagnosed with bowel cancer by the age of 85.

Under the National Bowel Cancer Screening Program, Australians aged between 50 and 74 receive a free bowel screening test every two years – an effective measure to promote early detection and treatment.

Although the risk of developing bowel cancer is higher in people aged over 50, an increasing number of younger Australians are being diagnosed with the disease. One in nine new bowel cancer cases now occur in Australians under the age of 50.

Professor Si Ming Man, also from ANU, said future bowel cancer screening methods could include checking the levels of Ku70 in pre-cancerous polyps, abnormal growths of tissue found in the colon, before healthy cells turn cancerous.

“Our research shows Ku70 is a good immune biomarker, meaning it helps us predict who will fare better or worse after being diagnosed with bowel cancer,” Professor Man said.

Ahead of World Cancer Day on 4 February, the ANU researchers are calling for people of all ages to be aware of the signs and symptoms of bowel cancer.

“We know early detection and treatment is vital to overcoming not only bowel cancer, but potentially other cancers as well,” Professor Man said.

“We hope the cancer research conducted at ANU helps raise awareness of cancer prevention, detection, and treatment on this important day.”

The research is published in Science Advances. Learn more about how ANU researchers are making important strides in cancer research at ANU Reporter.

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